Modern membrane physiology is a physiology of soap bubble.
Vladimir Matveev wrote:Yes, there is only one truth but if it is already discovered why science is needed?
***Na+K+ channel has a sense if membrane separates two solutions. But according to Ling' approach cell inside is NOT a solution, it is a gel where water properties is changed as a result of its interaction with proteins. From this point of view Na+K+ channel is not a CHANNEL, it is real protein structure connecting out cell water with inside gel. It is very important difference. Why? Read the references I gave above. So the channel MUST be regarded as receptor (sensor) only. This statement has a lot of sequences.
***The membrane theory (MT) is 100 years old. Research of cell structure was made independently from MT dogmas. As a result we have a lot of data inconsistent with the theory. Interestingly, who studies cell structure do not know MT exactly; who has established the main principles of MT are now dead.
***Some peculiarities of Ling's approach: (i) solutes distribution between cell and medium is ruled by its adsorption (or not) on intracellular structures (high K+ "concentration" into cell is accounted by its binding to proteins, no pumps);
(ii) bound intracellular water is a real barrier for extracellular solutes, not a plasma membrane;
iii) ATP is not the main energy source for cell, real source is an energy transformation accompanying the cycle: protein-water-K+-ATP protein + water + K+ + ADP + Pi; (iv) cell has no enough energy to supply even NaK-pump only postulated by MT.
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